Folic Acid & Vitamin B12 for treating Depression
May 21, 2018

The U.S. Navy Study - Folic acid (800 mcg) and Vitamin B12 (99 mcg)

Folic acid and vitamin B12 function together in many biochemical processes. Folic acid deficiency is the most common nutrient deficiency in the world. In studies of depressed patients, 31% to 35% have been shown to be deficient in folic acid. In elderly patients this percentage may be even higher. Studies have found that among elderly patients admitted to a psychiatric ward, the number with folic acid deficiency ranges from 35% to 92.6%. Depression is the most common symptom of a folic acid deficiency. Vitamin B12 deficiency is less common than that of folic acid deficiency, but it can also cause depression, especially in the elderly. Correcting folic acid and vitamin B12 deficiencies also results in a dramatic improvement in mood.

Folic acid, vitamin B12, and a form of the amino acid methionine known as SAMe (S-adenosylmethionine) function as "methyl donors". They carry and donate methyl molecules to important brain compounds including neurotransmitters. SAMe is the major methyl donor in the body. The antidepressant effects of folic acid appear to be a result of raising brain SAMe content.
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