Biotin is a member of the B vitamin family that functions in the manufacture and utilization of carbohydrates, fats, and amino acids. Without biotin, sugar metabolism is severely impaired. Biotin supplementation has been shown to enhance insulin sensitivity and increase the activity of the enzyme glucokinase - the enzyme responsible for the first step in the utilization of glucose by the liver. Glucokinase concentrations in diabetics are low. Evidently, supplementing the diet with high doses of biotin improves glucokinase activity and glucose metabolism in diabetics. In one study,16 mg of biotin daily resulted in significant lowering of fasting blood glucose levels and improvements in blood glucose control in type I diabetics. In another study in type II diabetics, similar effects were noted with 9 mg of biotin daily. Biotin therapy has also been shown to be quite helpful in the treatment of diabetic neuropathy.